Newt Gingrich would do the most damage to the national debt, followed by another big conservative spender, Rick Santorum.
The US Budget Watch says:
The United States faces a number of serious social and economic challenges. Federal budget deficits are projected for the foreseeable future, the economy remains weak, Social Security faces long-term financing concerns, health care spending is growing faster than the economy, tax policy is at a major crossroads, and our national debt continues to rise.
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